Sydney: A new gene therapy has been developed by a team of researchers that could help to ‘turn-off’ the immune response which causes allergic reaction such as asthma, or potentially lethal food allergies.<\/p>\n
Ray Steptoe, Associate Professor at the University of Queensland in Australia said,”When someone has an allergy or asthma flare-up, the symptoms they experience results from immune cells reacting to protein in the allergen.”<\/p>\n
The study showed that the single treatment may give life-long protection from asthma as well as those who have severe allergies to peanuts, bee venom, shell fish and other substances by de-sensitising the immune system to tolerate the protein.<\/p>\n
Steptoe said,”The challenge in asthma and allergies is that these immune cells, known as T-cells, develop a form of immune ‘memory’ and become very resistant to treatments.”<\/p>\n
He added,”We have now been able ‘wipe’ the memory of these T-cells in animals with gene therapy, de-sensitising the immune system so that it tolerates the protein.”<\/p>\n
For the study, the team took blood stem cells, and inserted a gene which regulated the allergen protein and put that into the recipients.<\/p>\n
Steptoe noted,”Those engineered cells produced new blood cells that express the protein and target specific immune cells, ‘turning off’ the allergic response.”<\/p>\n
He said, the eventual goal would be a single injected gene therapy, that is simpler and safer which could be used across a wide cross-section of affected individuals.<\/p>\n
The finding is detailed in the journal JCI Insight.<\/p>\n","protected":false},"excerpt":{"rendered":"
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