Tag: risks

Common sleeping pills linked with higher death risk

Common sleeping pills linked with higher death risk

PARIS, Feb 29 — Commonly-prescribed sleeping pills are linked to a more-than fourfold risk of premature death, according to an American study published in the journal BMJ Open on Monday.

These medications were also associated at higher doses with a 35-per cent increased risk of cancer as compared with non-users, but the reason for this is unclear.

Doctors led by Daniel Kripke of the Scripps Clinic Viterbi Family Sleep Center in La Jolla, California, looked at the medical records of more than 10,500 adults living in Pennsylvania who were taking prescribed sleeping aids.

These were compared against more than 23,600 counterparts, matched for age, health and background, who did not take these drugs.

The study ranged over two and a half years, and looked at widely-prescribed sleeping pills, including benzodiazepines, non-benzodiazepines, barbiturates and sedatives.

The overall number of deaths that occurred during this period was small in both groups, being less than a thousand in total.

But there was a striking difference in mortality, the researchers found.

Those who took between 18 and 132 doses of the pills per year were 4.6 times likelier to die than the “control” group.

Even those who took less than 18 annual doses were more than 3.5 times likelier to die.

“Rough order-of-magnitude estimates… suggest that in 2010, hypnotics (sleeping pills) may have been associated with 320,000 to 507,000 excess deaths in the USA alone,” says the study.

Details of how individuals died were not disclosed, and the authors stress that they have found a statistical link but not a cause.

But they sound the alarm, given the vast number of people who take these drugs.

“We estimate that approximately six to 10 per cent of US adults used these drugs in 2010 and the percentages may be higher in parts of Europe,” they write.

The average age of the people in the study was 54. The researchers say they took into account factors that could skew the comparison between the two groups, such as whether an individual smoked or had a pre-existing health condition.

However, they were unable to take depression, anxiety and other emotional factors into account, as these diagnoses are kept secret under Pennsylvania law.

Previous research into sleeping pills has found a link with car accidents and serious falls, “night-eating syndromes” of bingeing on food, regurgitation in the oesophagus and peptic ulcer disease. — AFPrelaxnews.com

Raw vegetables and fruits counteract heart risk genes

Raw vegetables and fruits counteract heart risk genes

People who are genetically susceptible to heart disease can lower their risk by eating plenty of fruit and raw vegetables, a study suggests.

It says five or more daily portions should be enough to counteract culprit versions of a gene on chromosome 9, thought to be possessed by a fifth of people of European ancestry.

Healthy diets appeared to weaken its effect.

The US researchers investigated more than 27,000 people for their work.

The findings were published in Plos Medicine journal.

These participants came from from around the globe, including Europe, China and Latin America.

The results suggest that individuals with high risk 9p21 gene versions who consumed a diet packed with raw vegetables, fruits and berries had a similar risk of heart attack as those with a low-risk variant of the same gene.

For the complete article, click here.